Many children on these medications may also have restricted movement due to underlying illness such as cerebral palsy, which also decreases bone mineral density. Children with CP have a higher fracture rate than the general population [Stevenson: 2006] and this fracture rate may be even higher in children with CP on antiepileptic medications. [Leet: 2006] Children with epilepsy may also be at an increased risk for falls due to seizures and ataxia, if present.
Children with decreased mobility and/or those on antiepileptic medications should have their diets optimized for calcium and vitamin D. Consideration of a referral to endocrinology should be given when children on antiepileptic medication have fractures and/or low bone mineral densities. Although there are no controlled treatment guidelines, children with a history of fractures and low bone mineral density may benefit by treatment with bisphosphonates, either weekly or monthly orally (alendronate or ibandronate) or every two months by IV infusion (pamidronate). [Valsamis: 2006] [Pack: 2003]
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|Author:||Lynne M Kerr, MD, PhD - 6/2011|
|Content Last Updated:||6/2011|
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