NF1: Growth

Individuals with neurofibromatosis type 1 are generally shorter than the general population with a larger head (relative macrocephaly). Specific growth charts for NF1 individuals are available and can prove useful in differentiating NF1-related issues from general pediatric causes of short stature. [Friedman: 1999] [Clementi: 1999]

Authors & Reviewers

Initial publication: September 2008; last update/revision: February 2009
Current Authors and Reviewers:
Author: David A. Stevenson, MD
Reviewers: Karin Dent, MS, CGC
David Viskochil, MD, Ph.D.

Page Bibliography

Clementi M, Milani S, Mammi I, Boni S, Monciotti C, Tenconi R.
Neurofibromatosis type 1 growth charts.
Am J Med Genet. 1999;87(4):317-323. PubMed abstract
Article reports growth differences in NF1.

Friedman JM, Gutmann DH, MacCollin M, Riccardi VM.
Neurofibromatosis: Phenotype, Natural History, and Pathogenesis.
3rd ed. Baltimore, MD: Johns Hopkins University Press; 1999. 080186285X
Excellent overview of NF1 by some of the world experts on NF1.

Szudek J, Birch P, Friedman JM.
Growth charts for young children with neurofibromatosis 1 (NF1).
Am J Med Genet. 2000;92(3):224-8. PubMed abstract
Contains growth charts specific for NF1.