Although folate acid supplementation has decreased the incidence of neural tube defects in the United States to somewhere between 25 and 45%, [Jägerstad: 2012] there are clearly other factors that are also important. In one area of the country, these included obesity, high serum homocysteine levels, low serum B12 levels, stress, and exposure to fumonisms, which are fungi produced toxins in corn grain. [Suarez: 2012]
ACOG practice bulletin. Neural tube defects. Number 44, July 2003. (Replaces committee opinion number 252, March 2001).
Int J Gynaecol Obstet. 2003;83(1):123-33. PubMed abstract
|Content Last Updated:||2/2009|
Folic acid fortification prevents neural tube defects and may also reduce cancer risks.
Acta Paediatr. 2012;101(10):1007-12. PubMed abstract
Suarez L, Felkner M, Brender JD, Canfield M, Zhu H, Hendricks KA.
Neural tube defects on the Texas-Mexico border: what we've learned in the 20 years since the Brownsville cluster.
Birth Defects Res A Clin Mol Teratol. 2012;94(11):882-92. PubMed abstract